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Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults

Boehme, R; Deserno, L; Gleich, T; Katthagen, T; Pankow, A; Behr, J; Buchert, R; ... Schlagenhauf, F; + view all (2015) Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults. Journal of Neuroscience , 35 (28) pp. 10103-10111. 10.1523/JNEUROSCI.0805-15.2015. Green open access

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Abstract

The striatum is known to play a key role in reinforcement learning, specifically in the encoding of teaching signals such as reward prediction errors (RPEs). It has been proposed that aberrant salience attribution is associated with impaired coding of RPE and heightened dopamine turnover in the striatum, and might be linked to the development of psychotic symptoms. However, the relationship of aberrant salience attribution, RPE coding, and dopamine synthesis capacity has not been directly investigated. Here we assessed the association between a behavioral measure of aberrant salience attribution, the salience attribution test, to neural correlates of RPEs measured via functional magnetic resonance imaging while healthy participants (n = 58) performed an instrumental learning task. A subset of participants (n = 27) also underwent positron emission tomography with the radiotracer [18F]fluoro-l-DOPA to quantify striatal presynaptic dopamine synthesis capacity. Individual variability in aberrant salience measures related negatively to ventral striatal and prefrontal RPE signals and in an exploratory analysis was found to be positively associated with ventral striatal presynaptic dopamine levels. These data provide the first evidence for a specific link between the constructs of aberrant salience attribution, reduced RPE processing, and potentially increased presynaptic dopamine function.

Type: Article
Title: Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.0805-15.2015
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.0805-15.2015
Language: English
Additional information: This version is the version of record [delete as appropriate]. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Aberrant Salience, Dopamine, Orbitofrontal Cortex, Prediction Error, Reinforcement Learning, Ventral Striatum, Unmedicated Schizophrenia-patients, Obsessive-compulsive Disorder, Prediction-error Signal, Ventral Tegmental Area, Orbitofrontal Cortex, Latent Inhibition, Motivational Signals, Parkinsons-disease, Nucleus-accumbens, Adaptive-behavior
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1491995
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