Scheuerle, RL;
Gerrard, SE;
Kendall, RA;
Tuleu, C;
Slater, NK;
Mahbubani, KT;
(2015)
Characterising the disintegration properties of tablets in opaque media using texture analysis.
International Journal of Pharmaceutics
, 486
(1-2)
pp. 136-143.
10.1016/j.ijpharm.2015.03.023.
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Abstract
Tablet disintegration characterisation is used in pharmaceutical research, development, and quality control. Standard methods used to characterise tablet disintegration are often dependent on visual observation in measurement of disintegration times. This presents a challenge for disintegration studies of tablets in opaque, physiologically relevant media that could be useful for tablet formulation optimisation. This study has explored an application of texture analysis disintegration testing, a non-visual, quantitative means of determining tablet disintegration end point, by analysing the disintegration behaviour of two tablet formulations in opaque media. In this study, the disintegration behaviour of one tablet formulation manufactured in-house, and Sybedia Flashtab placebo tablets in water, bovine, and human milk were characterised. A novel method is presented to characterise the disintegration process and to quantify the disintegration end points of the tablets in various media using load data generated by a texture analyser probe. The disintegration times in the different media were found to be statistically different (P<0.0001) from one another for both tablet formulations using one-way ANOVA. Using the Tukey post-hoc test, the Sybedia Flashtab placebo tablets were found not to have statistically significant disintegration times from each other in human versus bovine milk (adjusted P value 0.1685).
Type: | Article |
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Title: | Characterising the disintegration properties of tablets in opaque media using texture analysis |
Location: | Netherlands |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.ijpharm.2015.03.023 |
Publisher version: | http://dx.doi.org/10.1016/j.ijpharm.2015.03.023 |
Language: | English |
Additional information: | Copyright © 2015 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | Breast milk, Infant drug delivery, NSDS, Nipple shield delivery system, Rapidly disintegrating tablet, Texture analysis, Animals, Female, Humans, Milk, Milk, Human, Solubility, Tablets, Technology, Pharmaceutical, Water |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery.ucl.ac.uk/id/eprint/1491870 |
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