Bell, S;
Britton, A;
(2015)
Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.
Drug and Alcohol Dependence
, 155
pp. 111-117.
10.1016/j.drugalcdep.2015.08.008.
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Abstract
BACKGROUND: The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during midlife as a risk factor for developing depression during 28 years of follow-up. METHODS: We used data from a well characterised prospective cohort study (the Whitehall II study) of 7478 men and women (70% male) aged 35 to 55 years, and free from depression in 1985-1988, followed up regularly until 2013. Drinking pattern was defined in terms of usual and maximum amounts consumed within a single drinking session, total weekly volume of alcohol consumed and drinking frequency. Depression was assessed using the General Health Questionnaire Depression Subscale at multiple follow-up occasions (up to eight times in total). Associations between different drinking pattern components during midlife and depression were estimated using flexible parametric survival models. RESULTS: After adjustment for confounding factors only abstaining from alcohol during midlife was associated with an increased risk of developing depression during long-term observation. However, this association became non-significant after adjusting for baseline self-reported health. CONCLUSIONS: In this community dwelling population, drinking pattern during midlife was not associated with an increased risk of developing depression.
| Type: | Article |
|---|---|
| Title: | Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study. |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.drugalcdep.2015.08.008 |
| Publisher version: | http://doi.org/10.1016/j.drugalcdep.2015.08.008 |
| Language: | English |
| Additional information: | Copyright © 2017 Elsevier Ltd. All rights reserved. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Alcohol, Depression, Drinking pattern, Epidemiology, Longitudinal, Mental health, Adult, Alcohol Drinking, Depression, England, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1491592 |
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