UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

What is a normal blood glucose?

Güemes, M; Rahman, SA; Hussain, K; (2016) What is a normal blood glucose? Archives of Disease in Childhood , 101 (6) pp. 569-574. 10.1136/archdischild-2015-308336. Green open access

[thumbnail of Hussain_REVISED_Manuscript forArchives submission (3).pdf]
Preview
Text
Hussain_REVISED_Manuscript forArchives submission (3).pdf

Download (621kB) | Preview

Abstract

Glucose is the key metabolic substrate for tissue energy production. In the perinatal period the mother supplies glucose to the fetus and for most of the gestational period the normal lower limit of fetal glucose concentration is around 3 mmol/L. Just after birth, for the first few hours of life in a normal term neonate appropriate for gestational age, blood glucose levels can range between 1.4 mmol/L and 6.2 mmol/L but by about 72 h of age fasting blood glucose levels reach normal infant, child and adult values (3.5-5.5 mmol/L). Normal blood glucose levels are maintained within this narrow range by factors which control glucose production and glucose utilisation. The key hormones which regulate glucose homoeostasis include insulin, glucagon, epinephrine, norepinephrine, cortisol and growth hormone. Pathological states that affect either glucose production or utilisation will lead to hypoglycaemia. Although hypoglycaemia is a common biochemical finding in children (especially in the newborn) it is not possible to define by a single (or a range of) blood glucose value/s. It can be defined as the concentration of glucose in the blood or plasma at which the individual demonstrates a unique response to the abnormal milieu caused by the inadequate delivery of glucose to a target organ (eg, the brain). Hypoglycaemia should therefore be considered as a continuum and the blood glucose level should be interpreted within the clinical scenario and with respect to the counter-regulatory hormonal responses and intermediate metabolites.

Type: Article
Title: What is a normal blood glucose?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/archdischild-2015-308336
Publisher version: http://dx.doi.org/10.1136/archdischild-2015-308336
Language: English
Additional information: This article has been accepted for publication in Archives of Disease in Childhood following peer review. The definitive copyedited, typeset version, Güemes, M; Rahman, SA; Hussain, K; (2016) What is a normal blood glucose? Archives of Disease in Childhood, 101 (6) pp. 569-574. 10.1136/archdischild-2015-308336, is available online at: http://dx.doi.org/10.1136/archdischild-2015-308336.
Keywords: Diabetes, Endocrinology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/1490695
Downloads since deposit
6,007Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item