UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study

Balk, LJ; Cruz-Herranz, A; Albrecht, P; Arnow, S; Gelfand, JM; Tewarie, P; Killestein, J; ... Green, AJ; + view all (2016) Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study. Journal of Neurology , 263 (7) pp. 1323-1331. 10.1007/s00415-016-8127-y. Green open access

[thumbnail of Balk_Timing_retinal_neuronal.pdf]
Preview
Text
Balk_Timing_retinal_neuronal.pdf - Published Version

Download (860kB) | Preview

Abstract

The objective of the study was to investigate the timing of central nervous system tissue atrophy in MS by evaluating longitudinal retinal volume changes in a broadly representative cohort with disease duration across the entire arc of disease. In this longitudinal study, 135 patients with MS and 16 healthy reference subjects underwent spectral-domain optical coherence tomography (OCT) at baseline and 2 years later. Following OCT quality control, automated segmentation of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell–inner plexiform layer (mGCIPL) and macular inner nuclear layer (mINL) was performed. Generalized estimation equations were used to analyze longitudinal changes and associations with disease duration and clinical measures. Participants had a median disease duration at baseline of 16.4 years (range 0.1–45.4). Nearly half (44 %) of the MS patients had previously experienced MS-related optic neuritis (MSON) more than 6 months prior. The MS patients demonstrated a significant decrease over 2 years of the pRNFL (−1.1 µm, 95 % CI 1.4–0.7, p < 0.001) and mGCIPL (−1.1 µm, 95 % CI −1.4 to −0.8, p < 0.001). This thinning was most pronounced early in the course of disease. These findings were irrespective of previous episodes of MSON. No consistent pattern of change was observed for the mINL (−0.03 µm, 95 % CI −0.2 to 0.2, p = 0.795). This longitudinal study demonstrated that injury of the innermost retinal layers is found in MS and that this damage occurs most rapidly during the early stages of disease. The attenuation of atrophy with longer disease duration is suggestive of a plateau effect. These findings emphasize the importance of early intervention to prevent such injury.

Type: Article
Title: Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00415-016-8127-y
Publisher version: https://doi.org/10.1007/s00415-016-8127-y
Language: English
Additional information: Copyright © The Author(s) 2016. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Multiple sclerosis, Optical coherence tomography, Neurodegeneration, Retina, RNFL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1490327
Downloads since deposit
70Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item