UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The next level of 3D tumour models: immunocompetence

Nyga, A; Neves, J; Loizidou, M; Emberton, M; Cheema, U; (2016) The next level of 3D tumour models: immunocompetence. Drug Discovery Today , 21 (9) pp. 1421-1428. 10.1016/j.drudis.2016.04.010. Green open access

[thumbnail of Nyga_3D immune Nyga 2016 prepub.pdf]
Preview
Text
Nyga_3D immune Nyga 2016 prepub.pdf

Download (706kB) | Preview
[thumbnail of 3D immune Nyga 2016 epub.pdf]
Preview
Text
3D immune Nyga 2016 epub.pdf - Published version

Download (1MB) | Preview

Abstract

The complexity of the tumour microenvironment encompasses interactions between cancer and stromal cells. Moving from 2D cell culture methods into 3D models enables more-accurate investigation of those interactions. Current 3D cancer models focus on cancer spheroid interaction with stromal cells, such as fibroblasts. However, over recent years, the cancer immune environment has been shown to have a major role in tumour progression. This review summarises the state-of-art on immunocompetent 3D cancer models that, in addition to cancer cells, also incorporate immune cells, including monocytes, cancer-associated macrophages, dendritic cells, neutrophils and lymphocytes.

Type: Article
Title: The next level of 3D tumour models: immunocompetence
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.drudis.2016.04.010
Publisher version: http://dx.doi.org/10.1016/j.drudis.2016.04.010
Language: English
Additional information: Copyright © 2016 Elsevier Ltd. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1489992
Downloads since deposit
684Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item