Nyga, A;
Neves, J;
Loizidou, M;
Emberton, M;
Cheema, U;
(2016)
The next level of 3D tumour models: immunocompetence.
Drug Discovery Today
, 21
(9)
pp. 1421-1428.
10.1016/j.drudis.2016.04.010.
Preview |
Text
Nyga_3D immune Nyga 2016 prepub.pdf Download (706kB) | Preview |
Preview |
Text
3D immune Nyga 2016 epub.pdf - Published Version Download (1MB) | Preview |
Abstract
The complexity of the tumour microenvironment encompasses interactions between cancer and stromal cells. Moving from 2D cell culture methods into 3D models enables more-accurate investigation of those interactions. Current 3D cancer models focus on cancer spheroid interaction with stromal cells, such as fibroblasts. However, over recent years, the cancer immune environment has been shown to have a major role in tumour progression. This review summarises the state-of-art on immunocompetent 3D cancer models that, in addition to cancer cells, also incorporate immune cells, including monocytes, cancer-associated macrophages, dendritic cells, neutrophils and lymphocytes.
Archive Staff Only
![]() |
View Item |