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Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms

Sultan, P; David, AL; Fernando, R; Ackland, GL; (2016) Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms. Anesthesia & Analgesia , 122 (5) pp. 1546-1553. 10.1213/ANE.0000000000001195. Green open access

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Abstract

Intrapartum fever is associated with excessive maternal interventions as well as higher neonatal morbidity. Epidural-related maternal fever (ERMF) contributes to the development of intrapartum fever. The mechanism(s) for ERMF has remained elusive. Here, we consider how inflammatory mechanisms may be modulated by local anesthetic agents and their relevance to ERMF. We also critically reappraise the clinical data with regard to emerging concepts that explain how anesthetic drug-induced metabolic dysfunction, with or without activation of the inflammasome, might trigger the release of nonpathogenic, inflammatory molecules (danger-associated molecular patterns) likely to underlie ERMF.

Type: Article
Title: Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1213/ANE.0000000000001195
Publisher version: http://dx.doi.org/10.1213/ANE.0000000000001195
Language: English
Additional information: Copyright © 2016 International Anesthesia Research Society. Unauthorized reproduction of this article is prohibited. This is a non-final version of an article published in final form in Anesthesia & Analgesia: 122(5):1546-1553, May 2016 and available at http://dx.doi.org/10.1213/ANE.0000000000001195
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1489857
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