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Dissolution and drug release profiles of phosphate glasses doped with high valency oxides

El-Meliegy, E; Farag, MM; Knowles, JC; (2016) Dissolution and drug release profiles of phosphate glasses doped with high valency oxides. Journal of Materials Science: Materials in Medicine , 27 (6) , Article 108. 10.1007/s10856-016-5711-8. Green open access

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Abstract

This paper investigates phosphate glasses incorporating vanadium and molybdenum oxides for effective management of dissolution and drug release. These glass formulations are found to reduce the rate of dissolution from the glass surfaces. The drug functional groups of vancomycin molecules loaded by immersion showed stronger hydrogen bonding with Vanadium doped glasses and consequently lower rate of drug release over 2 weeks indicating better surface attachment with the drug molecules and slow drug release profiles. This can be explained by the strong adherence of drug molecules to glass surfaces compared with the molybdenum containing glasses (PM5 and PM10). The strong attachment relates to hydrogen bonding between the amino-functional groups of vancomycin and the hydrated P-O-H groups in the glass network. In conclusion, the rate of dissolution of doped glasses and the rate of drug release can be administered to deliver the drug molecules over weeks.

Type: Article
Title: Dissolution and drug release profiles of phosphate glasses doped with high valency oxides
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10856-016-5711-8
Publisher version: http://dx.doi.org/10.1007/s10856-016-5711-8
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-016-5711-8.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1489670
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