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Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis

Fletcher, PD; Downey, LE; Golden, HL; Clark, CN; Slattery, CF; Paterson, RW; Schott, JM; ... Warren, JD; + view all (2015) Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis. Cortex , 67 pp. 95-105. 10.1016/j.cortex.2015.03.021. Green open access

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Abstract

Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music ('musicophilia') occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.

Type: Article
Title: Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis
Location: Italy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cortex.2015.03.021
Publisher version: http://dx.doi.org/10.1016/j.cortex.2015.03.021
Language: English
Additional information: Copyright © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Affect, Alzheimer's disease, Environmental sounds, Frontotemporal dementia, Music, Musicophilia, Progressive aphasia, Reward, Semantic dementia, VBM, Affect, Aged, Aged, 80 and over, Alzheimer Disease, Auditory Perception, Brain, Emotions, Female, Frontotemporal Dementia, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Music, Nucleus Accumbens, Phenotype, Primary Progressive Nonfluent Aphasia, Temporal Lobe
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1488624
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