Hippert, C;
Graca, AB;
Pearson, RA;
(2015)
Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.
In: Rickman, CB and LaVail, MM and Anderson, RE and Grimm, C and Hollyfield, J and Ash, J, (eds.)
Retinal Degenerative Diseases: Mechanisms and Experimental Therapy.
(pp. pp. 579-585).
Springer: Cham, Switzerland.
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Abstract
Retinal degenerations leading to the loss of photoreceptor (PR) cells are a major cause of vision impairment and untreatable blindness. There are few clinical treatments and none can reverse the loss of vision. With the rapid advances in stem cell biology and techniques in cell transplantation, PR replacement by transplantation represents a broad treatment strategy applicable to many types of degeneration. The number of donor cells that integrate into the recipient retina determines transplantation success, yet the degenerating retinae presents a number of barriers that can impede effective integration. Here, we briefly review recent advances in the field of PR transplantation. We then describe how different aspects of gliosis may impact on cell integration efficiency.
| Type: | Proceedings paper |
|---|---|
| Title: | Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina |
| Event: | XVI International Symposium on Retinal Degeneration (RD2014) |
| ISBN-13: | 978-3-319-17120-3 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-17121-0_77 |
| Publisher version: | https://doi.org/10.1007/978-3-319-17121-0_77 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Gliosis, Müller glia, Intermediate filament, GFAP, CSPG, Photoreceptor transplantation, Barrier modulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1488576 |
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