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Nonlinear approach to difference imaging in diffuse optical tomography

Mozumder, M; Tarvainen, T; Seppanen, A; Nissila, I; Arridge, SR; Kolehmainen, V; (2015) Nonlinear approach to difference imaging in diffuse optical tomography. Journal of Biomedical Optics , 20 (10) , Article 105001. 10.1117/1.JBO.20.10.105001. Green open access

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Abstract

Difference imaging aims at recovery of the change in the optical properties of a body based on measurements before and after the change. Conventionally, the image reconstruction is based on using difference of the measurements and a linear approximation of the observation model. One of the main benefits of the linearized difference reconstruction is that the approach has a good tolerance to modeling errors, which cancel out partially in the subtraction of the measurements. However, a drawback of the approach is that the difference images are usually only qualitative in nature and their spatial resolution can be weak because they rely on the global linearization of the nonlinear observation model. To overcome the limitations of the linear approach, we investigate a nonlinear approach for difference imaging where the images of the optical parameters before and after the change are reconstructed simultaneously based on the two datasets. We tested the feasibility of the method with simulations and experimental data from a phantom and studied how the approach tolerates modeling errors like domain truncation, optode coupling errors, and domain shape errors.

Type: Article
Title: Nonlinear approach to difference imaging in diffuse optical tomography
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/1.JBO.20.10.105001
Publisher version: http://doi.org/10.1117/1.JBO.20.10.105001
Language: English
Additional information: © 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, or modification of the contents of the publication are prohibited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Optics, Radiology, Nuclear Medicine & Medical Imaging, Biochemistry & Molecular Biology, image reconstruction techniques, difference imaging, diffuse optical tomography, tomography, inverse problems, DENSE-SCATTERING MEDIA, PREMATURE-INFANT BRAIN, SPATIAL DECONVOLUTION, STRUCTURAL INFORMATION, APPROXIMATION ERRORS, DYNAMIC FEATURES, MODEL-REDUCTION, BLOOD-VOLUME, RECONSTRUCTION, REGULARIZATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1486771
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