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Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics

Timms, JF; Hale, OJ; Cramer, R; (2016) Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics. Expert Review of Proteomics , 13 (6) pp. 593-607. 10.1080/14789450.2016.1182431. Green open access

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Abstract

Introduction: The last 20 years have seen significant improvements in the analytical capabilities of biological mass spectrometry (MS). Studies using advanced MS have resulted in new insights into cell biology and the etiology of diseases as well as its use in clinical applications. / Areas covered: This review discusses recent developments in MS-based technologies and their cancer-related applications with a focus on proteomics. It also discusses the issues around translating the research findings to the clinic and provides an outline of where the field is moving. / Expert commentary: Proteomics has been problematic to adapt for the clinical setting. However, MS-based techniques continue to demonstrate potential in novel clinical uses beyond classical cancer proteomics.

Type: Article
Title: Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/14789450.2016.1182431
Publisher version: http://dx.doi.org/10.1080/14789450.2016.1182431
Language: English
Additional information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 6 May 2016, available online: http://dx.doi.org/10.1080/14789450.2016.1182431.
Keywords: Mass spectrometry, cancer research, cancer proteomics, clinical diagnostics, clinical mass spectrometry, mass spectrometry imaging, REIMS, MALDI, biotyping, pharmacokinetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/1485808
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