UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Pyrophosphate: a key inhibitor of mineralisation

Orriss, IR; Arnett, TR; Russell, RG; (2016) Pyrophosphate: a key inhibitor of mineralisation. Pyrophosphate: a key inhibitor of mineralisation , 28 pp. 57-68. 10.1016/j.coph.2016.03.003.

[img] Text
COPHAR 28, 57–68 (2016).pdf - Published version
Access restricted to UCL open access staff

Download (2MB)

Abstract

Inorganic pyrophosphate has long been known as a by-product of many intracellular biosynthetic reactions, and was first identified as a key endogenous inhibitor of biomineralisation in the 1960s. The major source of pyrophosphate appears to be extracellular ATP, which is released from cells in a controlled manner. Once released, ATP can be rapidly hydrolysed by ecto-nucleotide pyrophosphatase/phosphodiesterases to produce pyrophosphate. The main action of pyrophosphate is to directly inhibit hydroxyapatite formation thereby acting as a physiological 'water-softener'. Evidence suggests pyrophosphate may also act as a signalling molecule to influence gene expression and regulate its own production and breakdown. This review will summarise our current understanding of pyrophosphate metabolism and how it regulates bone mineralisation and prevents harmful soft tissue calcification.

Type: Article
Title: Pyrophosphate: a key inhibitor of mineralisation
DOI: 10.1016/j.coph.2016.03.003
Publisher version: http://dx.doi.org/10.1016/j.coph.2016.03.003
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1485669
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item