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The role of light in measuring ocular biomechanics

Wilson, A; Marshall, J; Tyrer, JR; (2016) The role of light in measuring ocular biomechanics. Eye , 30 (2) pp. 234-240. 10.1038/eye.2015.263. Green open access

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Abstract

The cornea is a highly specialised tissue with a unique set of biomechanical properties determined by its complex structure. The maintenance of these mechanical properties is fundamental to maintain clear vision as the cornea provides the majority of the focussing power of the eye. Changes to the biomechanics of the cornea can occur during ageing, disease, and trauma, or as a result of surgery. Recently there has been increased interest in the mechanical properties of the cornea as knowledge of these properties has significant implications for the improvement of current ocular treatments including PRK and LASIK, and for the diagnosis and tracking of corneal diseases and therapy such as keratoconus and crosslinking. Biomechanics are also important for the development of artificial corneal replacements. This paper describes the use of a novel, non-destructive lateral electronic speckle pattern shearing interferometer (ESPSI). The data generated via this technique give a full-field view of the mechanical response of the cornea under simulated physiological loading conditions, and enables strain and displacement to be determined in three planes. The technique allows corneal stiffness to be quantified and enables changes and non-homogeneities that occur due to surgery or disease to be detected.

Type: Article
Title: The role of light in measuring ocular biomechanics
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/eye.2015.263
Publisher version: http://doi.org/10.1038/eye.2015.263
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited All rights reserved.
Keywords: Pattern Shearing Interferometry, Goldmann Applanation Tonometry, Dynamic Contour Tonometry, Human Cornea, Human Eye, Elasticity, Collagen, Impact, Stroma, Depth
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1484162
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