UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Quantitative photoacoustic tomography using illuminations from a single direction.

Pulkkinen, A; Cox, BT; Arridge, SR; Kaipio, JP; Tarvainen, T; (2015) Quantitative photoacoustic tomography using illuminations from a single direction. Journal of Biomedical Optics , 20 (3) , Article 036015. 10.1117/1.JBO.20.3.036015. Green open access

[img]
Preview
Text
Pulkkinen_quantitative_photocoustic_tomography_using.pdf

Download (6MB) | Preview

Abstract

Quantitative photoacoustic tomography is an emerging imaging technique aimed at estimating optical parameters inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic propagation. This optical parameter estimation problem is ill-posed and needs to be approached within the framework of inverse problems. It has been shown that, in general, estimating the spatial distribution of more than one optical parameter is a nonunique problem unless more than one illumination pattern is used. Generally, this is overcome by illuminating the target from various directions. However, in some cases, for example when thick samples are investigated, illuminating the target from different directions may not be possible. In this work, the use of spatially modulated illumination patterns at one side of the target is investigated with simulations. The results show that the spatially modulated illumination patterns from a single direction could be used to provide multiple illuminations for quantitative photoacoustic tomography. Furthermore, the results show that the approach can be used to distinguish absorption and scattering inclusions located near the surface of the target. However, when compared to a full multidirection illumination setup, the approach cannot be used to image as deep inside tissues.

Type: Article
Title: Quantitative photoacoustic tomography using illuminations from a single direction.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/1.JBO.20.3.036015
Publisher version: http://dx.doi.org/ 10.1117/1.JBO.20.3.036015
Language: English
Additional information: Copyright © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. (https://creativecommons.org/licenses/by/3.0/) Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Keywords: photoacoustics; inverse problems; image reconstruction; radiative transfer
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1484161
Downloads since deposit
74Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item