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Induced pluripotent stem (iPS) cells from human fetal stem cells

Guillot, PV; (2016) Induced pluripotent stem (iPS) cells from human fetal stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology , 31 pp. 112-120. 10.1016/j.bpobgyn.2015.08.007. Green open access

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Abstract

Pluripotency defines the ability of stem cells to differentiate into all the lineages of the three germ layers and self-renew indefinitely. Somatic cells can regain the developmental potential of embryonic stem cells following ectopic expression of a set of transcription factors or, in certain circumstances, via modulation of culture conditions and supplementation with small molecule, that is, induced pluripotent stem (iPS) cells. Here, we discuss the use of fetal tissues for reprogramming, focusing in particular on stem cells derived from human amniotic fluid, and the development of chemical reprogramming. We next address the advantages and disadvantages of deriving pluripotent cells from fetal tissues and the potential clinical applications.

Type: Article
Title: Induced pluripotent stem (iPS) cells from human fetal stem cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpobgyn.2015.08.007
Publisher version: http://dx.doi.org/10.1016/j.bpobgyn.2015.08.007
Language: English
Additional information: © 2015 Elsevier Ltd. All rights reserved.This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: Reprogramming, small molecules, fetal stem cells, induced pluripotency, transcription factors, translational medicine, Mesenchymal Stromal Cells, Small-molecule Compounds, OCT4 Promoter Activity, Valproic Acid, Somatic-cells, Osteogenesis Imperfecta, Human Fibroblasts, Nuclear Transfer, Defined Factors, High-efficiency
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1484053
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