Bergles, DE;
Richardson, WD;
(2016)
Oligodendrocyte Development and Plasticity.
Cold Spring Harbor Perspectives in Biology
, 8
(2)
, Article a020453. 10.1101/cshperspect.a020453.
Text
Richardson_Bergles and Richardson (CSH Perspectives 2016).pdf Access restricted to UCL open access staff Download (7MB) |
Abstract
Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain and spinal cord and migrate throughout the developing central nervous system (CNS) before differentiating into myelinating oligodendrocytes (OLs). It is not known whether OPCs or OLs from different parts of the VZ are functionally distinct. OPCs persist in the postnatal CNS, where they continue to divide and generate myelinating OLs at a decreasing rate throughout adult life in rodents. Adult OPCs respond to injury or disease by accelerating their cell cycle and increasing production of OLs to replace lost myelin. They also form synapses with unmyelinated axons and respond to electrical activity in those axons by generating more OLs and myelin locally. This experience-dependent "adaptive" myelination is important in some forms of plasticity and learning, for example, motor learning. We review the control of OL lineage development, including OL population dynamics and adaptive myelination in the adult CNS.
Type: | Article |
---|---|
Title: | Oligodendrocyte Development and Plasticity |
Location: | United States |
DOI: | 10.1101/cshperspect.a020453 |
Publisher version: | http://dx.doi.org/10.1101/cshperspect.a020453 |
Language: | English |
Additional information: | Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
URI: | https://discovery.ucl.ac.uk/id/eprint/1483766 |
Archive Staff Only
View Item |