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The front and rear of collective cell migration

Mayor, R; Etienne-Manneville, S; (2016) The front and rear of collective cell migration. Nature Reviews Molecular Cell Biology , 17 (2) pp. 97-109. 10.1038/nrm.2015.14. Green open access

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Abstract

Collective cell migration has a key role during morphogenesis and during wound healing and tissue renewal in the adult, and it is involved in cancer spreading. In addition to displaying a coordinated migratory behaviour, collectively migrating cells move more efficiently than if they migrated separately, which indicates that a cellular interplay occurs during collective cell migration. In recent years, evidence has accumulated confirming the importance of such intercellular communication and exploring the molecular mechanisms involved. These mechanisms are based both on direct physical interactions, which coordinate the cellular responses, and on the collective cell behaviour that generates an optimal environment for efficient directed migration. The recent studies have described how leader cells at the front of cell groups drive migration and have highlighted the importance of follower cells and cell-cell communication, both between followers and between follower and leader cells, to improve the efficiency of collective movement.

Type: Article
Title: The front and rear of collective cell migration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrm.2015.14
Publisher version: http://doi.org/10.1038/nrm.2015.14
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited. All rights reserved.
Keywords: Cell adhesion, Cell migration, Collective cell migration
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1483697
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