Anderson, C;
Stern, CD;
(2016)
Organizers in Development.
In:
Current Topics in Developmental Biology: Essays on Developmental Biology, Part B.
(pp. 435-454).
Elsevier: Netherlands.
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Abstract
An "organizer" is formally defined as a region, or group of cells in an embryo that can both induce (change the fate) and pattern (generate an organized set of structures) adjacent embryonic cells. To date, about four such regions have been demonstrated: the primary or Spemann organizer (Hensen's node in amniotes), the notochord, the zone of polarizing activity of the limb bud, and the mid-hindbrain boundary. Here we review the evidence for these and compare them with a few other regions which have been proposed to represent other organizers and we speculate on why so few such regions have been discovered.
| Type: | Book chapter |
|---|---|
| Title: | Organizers in Development |
| Location: | United States |
| DOI: | 10.1016/bs.ctdb.2015.11.023 |
| Publisher version: | http://dx.doi.org/10.1016/bs.ctdb.2015.11.023 |
| Language: | English |
| Keywords: | Floor plate induction, Hensen's node, Neural induction, Notochord, Patterning, Primary organizer, Secondary organizers, Signaling, Spemann–Mangold organizer, Zone of polarizing activity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1483471 |
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