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NRP1 function and targeting in neurovascular development and eye disease

Raimondi, C; Brash, JT; Fantin, A; Ruhrberg, C; (2016) NRP1 function and targeting in neurovascular development and eye disease. Progress in Retinal and Eye Research , 52 pp. 64-83. 10.1016/j.preteyeres.2016.02.003. Green open access

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Abstract

Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 function, and a multitude of therapeutics targeting NRP1 have been designed, mostly with the view to explore them for cancer treatment. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1, with particular focus on neuronal and vascular roles in the brain and retina. This review will also discuss the potential of NRP1 inhibitors for the treatment for neovascular eye diseases.

Type: Article
Title: NRP1 function and targeting in neurovascular development and eye disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.preteyeres.2016.02.003
Publisher version: http://dx.doi.org/10.1016/j.preteyeres.2016.02.003
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Ophthalmology, Angiogenesis, Neovascularisation, Vascular permeability, Endothelial cell, Neuropilin, ENDOTHELIAL GROWTH-FACTOR, RETINAL VEIN OCCLUSION, VASCULAR-PERMEABILITY FACTOR, PERIPHERAL-NERVE PROJECTION, OXYGEN-INDUCED RETINOPATHY, ADVANCED SOLID TUMORS, END-RULE PEPTIDES, VEGF-A BINDING, SEMAPHORIN 3A, NEUROPILIN 1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1483451
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