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Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation

Quaglia, A; Alves, VA; Balabaud, C; Bhathal, PS; Bioulac-Sage, P; Crawford, JM; Dhillon, AP; ... van Leeuwen, DJ; + view all (2016) Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation. Histopathology , 68 (7) pp. 953-967. 10.1111/his.12957. Green open access

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Abstract

Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes. The old paradigm of ‘irreversibility’ of cirrhosis had been challenged in major ways, and the validity of the usage of the term ‘cirrhosis’ has come into question. This paper addresses aetiology-based clinicopathological concepts and features that may deserve attention because they may determine disease outcome and, specifically, patterns of regression and remodelling. A variety of therapeutic interventions may influence remaining disease features after elimination of damaging agents (virus, alcohol, etc.), and determine the final clinical outcome including the risk of hepatocellular carcinoma (HCC). New concepts create new responsibilities and opportunities for the pathologist to contribute to the understanding of liver pathology and communicate this with clinical colleagues and researchers.

Type: Article
Title: Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/his.12957
Publisher version: http://dx.doi.org/10.1111/his.12957
Language: English
Additional information: This is the peer reviewed version of the following article: Quaglia, A; Alves, VA; Balabaud, C; Bhathal, PS; Bioulac-Sage, P; Crawford, JM; Dhillon, AP; (2016) Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation. Histopathology, 68 (7) pp. 953-967, which has been published in final form at http://dx.doi.org/10.1111/his.12957. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Pathology, biopsy, end stage liver disease, fibrosis, liver cirrhosis, liver regeneration, Chronic Hepatitis-b, Nonalcoholic Steatohepatitis, Alcoholic Hepatitis, Natural-history, Ductular Reaction, Idiopathic Hemochromatosis, Histological Improvement, Micronodular Cirrhosis, Fibrosis Progression, Autoimmune Hepatitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1483165
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