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Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature

Al-Armaghany, A; Tong, K; Highton, D; Leung, TS; (2016) Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature. In: Elwell, CE and Leung, TS and Harrison, DK, (eds.) Oxygen Transport to Tissue XXXVII. (pp. 435-441). Springer: New York, NY, USA. Green open access

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Abstract

We have previously developed a hybrid microwave-optical system to monitor microvascular changes in response to thermal provocation in muscle. The hybrid probe is capable of inducing deep heat from the skin surface using mild microwaves (1–3 W) and raises the tissue temperature by a few degrees Celsius. This causes vasodilation and the subsequent increase in blood volume is detected by the hybrid probe using near infrared spectroscopy. The hybrid probe is also equipped with a skin cooling system which lowers the skin temperature while allowing microwaves to warm up deeper tissues. The hybrid system can be used to assess the condition of the vasculature in response to thermal stimulation. In this validation study, thermal imaging has been used to assess the temperature distribution on the surface of phantoms and human calf, following microwave warming. The results show that the hybrid system is capable of changing the skin temperature with a combination of microwave warming and skin cooling. It can also detect thermal responses in terms of changes of oxy/deoxy-hemoglobin concentrations.

Type: Book chapter
Title: Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature
ISBN-13: 9781493930227
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4939-3023-4_55
Publisher version: http://dx.doi.org/10.1007/978-1-4939-3023-4_55
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Medicine, Research & Experimental, Physiology, Research & Experimental Medicine, Near infrared spectroscopy, Thermoregulation, Vasodilation, Muscle, Microwave applicator
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1483134
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