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Lipid transfer proteins do their thing anchored at membrane contact sites… but what is their thing?

Wong, LH; Levine, TP; (2016) Lipid transfer proteins do their thing anchored at membrane contact sites… but what is their thing? Biochemical Society Transactions , 44 (2) pp. 517-527. 10.1042/BST20150275. Green open access

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Abstract

Membrane contact sites are structures where two organelles come close together to regulate flow of material and information between them. One type of inter-organelle communication is lipid exchange, which must occur for membrane maintenance and in response to environmental and cellular stimuli. Soluble lipid transfer proteins have been extensively studied, but additional families of transfer proteins have been identified that are anchored into membranes by transmembrane helices so that they cannot diffuse through the cytosol to deliver lipids. If such proteins target membrane contact sites they may be major players in lipid metabolism. The eukaryotic family of so-called Lipid transfer proteins Anchored at Membrane contact sites (LAMs) all contain both a sterol-specific lipid transfer domain in the StARkin superfamily (related to StART/Bet_v1), and one or more transmembrane helices anchoring them in the endoplasmic reticulum (ER), making them interesting subjects for study in relation to sterol metabolism. They target a variety of membrane contact sites, including newly described contacts between organelles that were already known to make contact by other means. Lam1-4p target punctate ER-plasma membrane contacts. Lam5p and Lam6p target multiple contacts including a new category: vacuolar non-NVJ cytoplasmic ER (VancE) contacts. These developments confirm previous observations on tubular lipid-binding proteins (TULIPs) that established the importance of membrane anchored proteins for lipid traffic. However, the question remaining to be solved is the most difficult of all: are LAMs transporters, or alternately are they regulators that affect traffic more indirectly?

Type: Article
Title: Lipid transfer proteins do their thing anchored at membrane contact sites… but what is their thing?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BST20150275
Publisher version: http://dx.doi.org/10.1042/BST20150275
Language: English
Additional information: Copyright © 2016 Authors; published by Portland Press Limited.
Keywords: biological transport, ergosterol/analogues and derivatives/chemistry, intracellular membranes/*metabolism, membrane lipids/metabolism, proteins/genetics/*metabolism, proteins/genetics/metabolism, saccharomyces cerevisiae, vesicular transport
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1483127
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