Yadav, S;
Cockcroft, S;
Raghu, P;
(2016)
The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites.
Biochemical Society Transactions
, 44
(2)
pp. 447-451.
10.1042/BST20150256.
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Abstract
Several recent studies have demonstrated the existence of membrane contact sites (MCS) between intracellular organelles in eukaryotic cells. Recent exciting studies have also demonstrated the existence of biomolecular interactions at these contact sites in mediating changes in the membrane composition of the cellular compartments. However, the role of such contact sites in regulating organelle function and physiological processes remains less clear. In this review we discuss the existence of a contact site between the plasma membrane (PM) and the endoplasmic reticulum (ER) inDrosophilaphotoreceptors. Further, we discuss the role of specific proteins present at this location in regulating phospholipid turnover and its impact in regulating a physiological process, namely phototransduction.
Type: | Article |
---|---|
Title: | The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1042/BST20150256 |
Publisher version: | http://doi.org/10.1042/BST20150256 |
Language: | English |
Additional information: | © 2016 Authors; published by Portland Press Limited |
Keywords: | 5)P2] turnover, 5-bisphosphate [PI(4, Drosophila, RDGB, lipid transfer proteins, membrane contact sites, micovillar photoreceptors, phosphatidylinositol 4 Micovillar photoreceptors, membrane contact sites, PI(4,5)P2 turnover, lipid transfer proteins, RDGB, Drosophila |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
URI: | https://discovery.ucl.ac.uk/id/eprint/1482952 |
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