Goldman, AM;
Behr, ER;
Semsarian, C;
Bagnall, RD;
Sisodiya, S;
Cooper, PN;
(2016)
Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention.
Epilepsia
, 57
(S1)
pp. 17-25.
10.1111/epi.13232.
Text
Sidosiya_Goldman_et_al-2016-Epilepsia.pdf Access restricted to UCL open access staff Download (141kB) |
Abstract
Epidemiologic studies clearly document the public health burden of sudden unexpected death in epilepsy (SUDEP). Clinical and experimental studies have uncovered dynamic cardiorespiratory dysfunction, both interictally and at the time of sudden death due to epilepsy. Genetic analyses in humans and in model systems have facilitated our current molecular understanding of SUDEP. Many discoveries have been informed by progress in the field of sudden cardiac death and sudden infant death syndrome. It is becoming apparent that SUDEP genomic complexity parallels that of sudden cardiac death, and that there is a pauci1ty of analytically useful postmortem material. Because many challenges remain, future progress in SUDEP research, molecular diagnostics, and prevention rests in international, collaborative, and transdisciplinary dialogue in human and experimental translational research of sudden death.
Type: | Article |
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Title: | Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention |
Location: | United States |
DOI: | 10.1111/epi.13232 |
Publisher version: | http://dx.doi.org/10.1111/epi.13232 |
Language: | English |
Keywords: | Molecular autopsy, Prevention, Sudden cardiac death, Sudden infant death syndrome, Sudden unexpected death in epilepsy (SUDEP), genetics |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
URI: | https://discovery.ucl.ac.uk/id/eprint/1482643 |
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