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The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor

Rigoli, F; Chew, B; Dayan, P; Dolan, RJ; (2016) The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor. Journal of Cognitive Neuroscience , 28 (9) pp. 1303-1317. 10.1162/jocn_a_00972. Green open access

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Abstract

Dopamine plays a key role in motivation. Phasic dopamine response reflects a reinforcement prediction error (RPE), whereas tonic dopamine activity is postulated to represent an average reward that mediates motivational vigor. However, it has been hard to find evidence concerning the neural encoding of average reward that is uncorrupted by influences of RPEs. We circumvented this difficulty in a novel visual search task where we measured participants' button pressing vigor in a context where information (underlying an RPE) about future average reward was provided well before the average reward itself. Despite no instrumental consequence, participants' pressing force increased for greater current average reward, consistent with a form of Pavlovian effect on motivational vigor. We recorded participants' brain activity during task performance with fMRI. Greater average reward was associated with enhanced activity in dopaminergic midbrain to a degree that correlated with the relationship between average reward and pressing vigor. Interestingly, an opposite pattern was observed in subgenual cingulate cortex, a region implicated in negative mood and motivational inhibition. These findings highlight a crucial role for dopaminergic midbrain in representing aspects of average reward and motivational vigor.

Type: Article
Title: The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1162/jocn_a_00972
Publisher version: http://doi.org/10.1162/jocn_a_00972
Language: English
Additional information: © 2016 Massachusetts Institute of Technology. Rigoli, F; Chew, B; Dayan, P; Dolan, RJ; (2016) The Dopaminergic Midbrain Mediates an Effect of Average Reward on Pavlovian Vigor. Journal of Cognitive Neuroscience , 28 (9) pp. 1303-1317. 10.1162/jocn_a_00972. http://www.mitpressjournals.org/loi/jocn
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit
URI: https://discovery.ucl.ac.uk/id/eprint/1482521
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