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Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease

Torii, R; Parker, KH; Yacoub, MH; (2016) Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease. [Letter]. Journal of the American College of Cardiology , 67 (14) pp. 1755-1756. 10.1016/j.jacc.2015.12.069. Green open access

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Abstract

We read the paper by Guzzardi et al. (1) with great interest. These investigators demonstrate the effects of specific types of aortic valve anomaly on the pattern of aortic wall shear stress (WSS) measured by 4-dimensional cardiovascular magnetic resonance (CMR) and the relationships among WSS, ascending aorta shape and dilation, and wall degeneration. We have previously shown that increased WSS quantified by computational fluid dynamics (CFD) on the basis of pre-operative magnetic resonance imaging coincided with severe disruption of the media of the aorta, as documented by histological examination (Figure 1) (2). The findings of Guzzardi et al. (1) confirm and extend our previous findings.

Type: Article
Title: Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jacc.2015.12.069
Publisher version: http://dx.doi.org/10.1016/j.jacc.2015.12.069
Language: English
Additional information: Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Keywords: Aorta, Aortic Valve, Female, Heart Valve Diseases, Humans, Male
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1482430
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