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Persistent changes in peripheral and spinal nociceptive processing after early tissue injury

Walker, SM; Beggs, S; Baccei, ML; (2016) Persistent changes in peripheral and spinal nociceptive processing after early tissue injury. Experimental Neurology , 275 (Part 2) pp. 253-260. 10.1016/j.expneurol.2015.06.020. Green open access

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Abstract

It has become clear that tissue damage during a critical period of early life can result in long-term changes in pain sensitivity, but the underlying mechanisms remain to be fully elucidated. Here we review the clinical and preclinical evidence for persistent alterations in nociceptive processing following neonatal tissue injury, which collectively point to the existence of both a widespread hypoalgesia at baseline as well as an exacerbated degree of hyperalgesia following a subsequent insult to the same somatotopic region. We also highlight recent work investigating the effects of early trauma on the organization and function of ascending pain pathways at a cellular and molecular level. These effects of neonatal injury include altered ion channel expression in both primary afferent and spinal cord neurons, shifts in the balance between synaptic excitation and inhibition within the superficial dorsal horn (SDH) network, and a ‘priming’ of microglial responses in the adult SDH. A better understanding of how early tissue damage influences the maturation of nociceptive circuits could yield new insight into strategies to minimize the long-term consequences of essential, but invasive, medical procedures on the developing somatosensory system.

Type: Article
Title: Persistent changes in peripheral and spinal nociceptive processing after early tissue injury
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.expneurol.2015.06.020
Publisher version: http://dx.doi.org/10.1016/j.expneurol.2015.06.020
Language: English
Additional information: Copyright © 2015 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Neonatal, Surgical incision, Inflammation, Microglia, Pain, Spinal cord, Dorsal horn, Synapse, Patch clamp, DRG, Primary afferent, Glutamate, GABA, Glycine, Membrane excitability, Superficial Dorsal-horn, Sensory Neurite Outgrowth, Local Inflammatory Insult, Neonatally Wounded Skin, Long-term Consequences, Central nervous system, Lamina-I Neurons, Adult-rat, Neuropathic Pain, Growth factor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1482395
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