UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Low-dose x-ray phase contrast tomography: Experimental setup, image reconstruction and applications in biomedicine

Hagen, CK; Zamir, A; Diemoz, PC; Endrizzi, M; Kennedy, F; Jager, RH; Olivo, A; (2014) Low-dose x-ray phase contrast tomography: Experimental setup, image reconstruction and applications in biomedicine. In: 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). (pp. pp. 1-5). IEEE: Seattle, WA, United States. Green open access

[img]
Preview
Text
Hagen_ProcIEEE_2014.pdf - Accepted version

Download (1MB) | Preview

Abstract

An unmet demand for high resolution tomographic imaging modalities providing enhanced soft tissue contrast exists in a number of biomedical disciplines. X-ray phase contrast imaging (XPCi) methods can provide a solution: contrast is driven by phase (refraction) effects rather than attenuation effects, the formers being much larger than the latters for weakly attenuating materials and energies typically used for biomedical imaging. However, the majority of the existing XPCi methods suffer from drawbacks affecting their implementation outside specialized facilities such as synchrotrons and therefore their applicability to biomedical research. The Edge Illumination (EI) XPCi method has the potential to overcome or at least mitigate most of these drawbacks. Its major strengths are its simple setup, compatibility with commercially available x-ray tubes and potential for low-dose imaging. EI XPCi has recently been implemented as a tomographic modality, and it was demonstrated that the method can provide quantitatively accurate volumetric images acquired with low entrance doses. This paper explains the experimental requirements for tomographic EI XPCi, outlines the image reconstruction process and discusses potential applications in biomedicine. As an example, first experimental images of an atherosclerotic plaque specimen are presented.

Type: Proceedings paper
Title: Low-dose x-ray phase contrast tomography: Experimental setup, image reconstruction and applications in biomedicine
Event: 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Location: Seattle, WA
Dates: 08 November 2014 - 15 November 2014
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSSMIC.2014.7430971
Publisher version: http://dx.doi.org/10.1109/NSSMIC.2014.7430971
Language: English
Additional information: Copyright © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1482188
Downloads since deposit
89Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item