Cambiano, V;
Miners, A;
Phillips, A;
(2016)
What do we know about the cost- effectiveness of HIV preexposure prophylaxis, and is it affordable?
Current Opinion in HIV and AIDS
, 11
(1)
pp. 56-66.
10.1097/COH.0000000000000217.
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Abstract
PURPOSE OF REVIEW: The WHO recommends preexposure prophylaxis (PrEP) in populations at substantial risk of HIV. Despite a number of randomized controlled trials demonstrating its efficacy, and several ongoing implementation projects, PrEP is currently only available in a few countries. Modelling studies can provide useful insights into the long-term impact of introducing PrEP in different subgroups of the population. The review summarizes studies that either evaluated the cost–effectiveness or the cost of introducing PrEP, focusing on seven published in the last year. RECENT FINDINGS: These studies used a number of different types of models and investigated the introduction of PrEP in different settings. Among men having sex with men (MSM) in North America, PrEP ranged from being cost-saving (while benefiting population health) to costing US $160 000/quality-adjusted life-year gained. Among heterosexual sero-different couples, it varied from around US $5000 to US $10 000/disability-adjusted life-year averted, when PrEP was used until 6 or 12 months after the HIV-positive partner had initiated antiretroviral therapy (ART) in, respectively, Uganda and South Africa. SUMMARY: Future cost–effectiveness studies of PrEP should consider the HIV incidence, the level of uptake, the effect of its introduction on alternative prevention approaches, and the budget impact of rolling it out.
Type: | Article |
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Title: | What do we know about the cost- effectiveness of HIV preexposure prophylaxis, and is it affordable? |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1097/COH.0000000000000217 |
Publisher version: | http://dx.doi.org/10.1097/COH.0000000000000217 |
Language: | English |
Additional information: | This is a non-final version of an article published in final form in Cambiano, V; Miners, A; Phillips, A; (2016) What do we know about the cost- effectiveness of HIV preexposure prophylaxis, and is it affordable? Current Opinion in HIV and AIDS , 11 (1) pp. 56-66. 10.1097/COH.0000000000000217. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, affordability, cost-effectiveness, HIV prevention, modelling, preexposure prophylaxis, BUDGET IMPACT ANALYSIS, PREVENTION, MEN, SEX |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/1482057 |
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