UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging

Vukmanovic-Stejic, M; Sandhu, D; Seidel, JA; Patel, N; Sobande, TO; Agius, E; Jackson, SE; ... Akbar, AN; + view all (2015) The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging. Journal Of Investigative Dermatology , 135 (7) pp. 1752-1762. 10.1038/jid.2015.63. Green open access

[thumbnail of Vukmanovic-Stejic_Characterization_Varicella_Zoster_Virus-Specific.pdf]
Preview
Text
Vukmanovic-Stejic_Characterization_Varicella_Zoster_Virus-Specific.pdf

Download (2MB) | Preview

Abstract

Reactivation of the varicella zoster virus (VZV) increases during aging. Although the effects of VZV reactivation are observed in the skin (shingles), the number and functional capacity of cutaneous VZV-specific T cells have not been investigated. The numbers of circulating IFN-γ-secreting VZV-specific CD4+ T cells are significantly decreased in old subjects. However, other measures of VZV-specific CD4+ T cells, including proliferative capacity to VZV antigen stimulation and identification of VZV-specific CD4+ T cells with an major histocompatibility complex class II tetramer (epitope of IE-63 protein), were similar in both age groups. The majority of T cells in the skin of both age groups expressed CD69, a characteristic of skin-resident T cells. VZV-specific CD4+ T cells were significantly increased in the skin compared with the blood in young and old subjects, and their function was similar in both age groups. In contrast, the number of Foxp3+ regulatory T cells and expression of the inhibitory receptor programmed cell death -1 PD-1 on CD4+ T cells were significantly increased in the skin of older humans. Therefore, VZV-specific CD4+ T cells in the skin of older individuals are functionally competent. However, their activity may be restricted by multiple inhibitory influences in situ.

Type: Article
Title: The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/jid.2015.63
Publisher version: https://doi.org/10.1038/jid.2015.63
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: T cell, memory, skin resident, antigen-specific, ageing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1481649
Downloads since deposit
158Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item