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HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Yaldizli, Ö; Sethi, V; Pardini, M; Tur, C; Mok, KY; Muhlert, N; Liu, Z; ... Chard, DT; + view all (2016) HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis. Multiple Sclerosis and Related Disorders , 7 pp. 47-52. 10.1016/j.msard.2016.03.003. Green open access

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Abstract

Background: The HLA-DRB∗1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To assess HLA-DRB∗1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. / Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB∗1501 haplotype was determined by genotyping (rs3135388). / Results: No significant differences were observed in MRI measures between the HLA-DRB∗1501 subgroups. / Conclusions: The HLA-DRB∗1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

Type: Article
Title: HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msard.2016.03.003
Publisher version: http://dx.doi.org/10.1016/j.msard.2016.03.003
Language: English
Additional information: © 2016. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Keywords: Multiple sclerosis; Grey matter; Magnetization transfer ratio; HLA-DRB*1501; Cortical lesion
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1481372
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