UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Microtubules, polarity and vertebrate neural tube morphogenesis

Cearns, MD; Escuin, S; Alexandre, P; Greene, ND; Copp, AJ; (2016) Microtubules, polarity and vertebrate neural tube morphogenesis. Journal of Anatomy , 229 (1) pp. 63-74. 10.1111/joa.12468. Green open access

[thumbnail of Cearns_Microtubules, polarity and vertebrate neural tube morphogenesis.pdf]
Preview
Text
Cearns_Microtubules, polarity and vertebrate neural tube morphogenesis.pdf

Download (765kB) | Preview

Abstract

Microtubules (MTs) are key cellular components, long known to participate in morphogenetic events that shape the developing embryo. However, the links between the cellular functions of MTs, their effects on cell shape and polarity, and their role in large-scale morphogenesis remain poorly understood. Here, these relationships were examined with respect to two strategies for generating the vertebrate neural tube: bending and closure of the mammalian neural plate; and cavitation of the teleost neural rod. The latter process has been compared with 'secondary' neurulation that generates the caudal spinal cord in mammals. MTs align along the apico-basal axis of the mammalian neuroepithelium early in neural tube closure, participating functionally in interkinetic nuclear migration, which indirectly impacts on cell shape. Whether MTs play other functional roles in mammalian neurulation remains unclear. In the zebrafish, MTs are important for defining the neural rod midline prior to its cavitation, both by localizing apical proteins at the tissue midline and by orienting cell division through a mirror-symmetric MT apparatus that helps to further define the medial localization of apical polarity proteins. Par proteins have been implicated in centrosome positioning in neuroepithelia as well as in the control of polarized morphogenetic movements in the neural rod. Understanding of MT functions during early nervous system development has so far been limited, partly by techniques that fail to distinguish 'cause' from 'effect'. Future developments will likely rely on novel ways to selectively impair MT function in order to investigate the roles they play.

Type: Article
Title: Microtubules, polarity and vertebrate neural tube morphogenesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/joa.12468
Publisher version: http://dx.doi.org/10.1111/joa.12468
Language: English
Additional information: Copyright © 2016 Anatomical Society. This is the peer reviewed version of the following article: [Cearns, M. D., Escuin, S., Alexandre, P., Greene, N. D. E. and Copp, A. J. (2016), Microtubules, polarity and vertebrate neural tube morphogenesis. Journal of Anatomy, 229: 63–74. doi: 10.1111/joa.12468], which has been published in final form at http://dx.doi.org/10.1111/joa.12468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Microtubules, amphibia, zebrafish, cell polarity, morphogenesis, mouse, chick, neural tube, neurulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1481240
Downloads since deposit
97Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item