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Application of diffusion-edited and solvent suppression (1) H-NMR to the direct analysis of markers in valerian-hop liquid herbal products

Prieto, JM; Mellinas-Gomez, M; Zloh, M; (2016) Application of diffusion-edited and solvent suppression (1) H-NMR to the direct analysis of markers in valerian-hop liquid herbal products. Phytochemical Analysis , 27 (2) pp. 100-106. 10.1002/pca.2603.

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Abstract

Introduction - The rising trend to consume herbal products for the treatment and/or prevention of minor ailments together with their chemical and pharmacological complexity means there is an urgent need to develop new approaches to their quality and stability. Objectives - This work looks at the application of one-dimensional diffusion-edited (1) H-NMR spectroscopy (1D DOSY) and (1) H-NMR with suppression of the ethanol and water signals to the characterisation of quality and stability markers in multi-component herbal medicines/food supplements. Material and Methods - The experiments were performed with commercial tinctures of Valeriana officinalis L. (valerian), expired and non-expired, as well as its combination with Hummulus lupulus L. (hops), which is one of the most popular blends of relaxant herbs. These techniques did not require purification or evaporation of components for the qualitative analysis of the mixture, but only the addition of D2 O and TSP. Results - The best diagnostic signals were found at δ 7 ppm (H-11, valerenic acid), δ 4.2 ppm (H-1, hydroxyvalerenic acid) and δ 1.5-1.8 ppm (methyl groups in prenylated moieties, α-acids/prenylated flavones). Conclusion - This work concludes on the potential value of 1D DOSY (1) H-NMR to provide additional assurance of quality in complex natural mixtures. Copyright © 2016 John Wiley & Sons, Ltd.

Type: Article
Title: Application of diffusion-edited and solvent suppression (1) H-NMR to the direct analysis of markers in valerian-hop liquid herbal products
Location: England
DOI: 10.1002/pca.2603
Publisher version: http://dx.doi.org/10.1002/pca.2603
Language: English
Additional information: Copyright © 2016 John Wiley & Sons, Ltd. This is the peer reviewed version of the following Prieto, JM; Mellinas-Gomez, M; Zloh, M; (2016) Application of diffusion-edited and solvent suppression (1) H-NMR to the direct analysis of markers in valerian-hop liquid herbal products. Phytochemical Analysis , 27 (2) pp. 100-106 which has been published in final form at http://dx.doi.org/10.1002/pca.2603 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving, http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms
Keywords: Herbal medicinal product, Humulus lupulus L, Valeriana officinalis, diffusion edited spectroscopy, nuclear magnetic resonance, quality marker
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > SoP Pharmaceutical and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1481100
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