Omnus, DJ;
Manford, AG;
Bader, JM;
Emr, SD;
Stefan, CJ;
(2016)
Phosphoinositide kinase signaling controls ER-PM cross-talk.
Molecular Biology of the Cell
, 27
(7)
pp. 1170-1180.
10.1091/mbc.E16-01-0002.
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Abstract
Membrane lipid dynamics must be precisely regulated for normal cellular function, and disruptions in lipid homeostasis are linked to the progression of several diseases. However, little is known about the sensory mechanisms for detecting membrane composition and how lipid metabolism is regulated in response to membrane stress. We find that phosphoinositide (PI) kinase signaling controls a conserved PDK-TORC2-Akt signaling cascade as part of a homeostasis network that allows the endoplasmic reticulum (ER) to modulate essential responses, including Ca(2+)-regulated lipid biogenesis, upon plasma membrane (PM) stress. Furthermore, loss of ER-PM junctions impairs this protective response, leading to PM integrity defects upon heat stress. Thus PI kinase-mediated ER-PM cross-talk comprises a regulatory system that ensures cellular integrity under membrane stress conditions.
| Type: | Article |
|---|---|
| Title: | Phosphoinositide kinase signaling controls ER-PM cross-talk |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1091/mbc.E16-01-0002 |
| Publisher version: | http://dx.doi.org/10.1091/mbc.E16-01-0002 |
| Language: | English |
| Additional information: | Copyright © 2016 Omnus, Manford, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by -nc-sa/3.0). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1481072 |
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