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Local and global contributions to hemodynamic activity in mouse cortex

Pisauro, MA; Benucci, A; Carandini, M; (2016) Local and global contributions to hemodynamic activity in mouse cortex. Journal of Neurophysiology , 115 (6) pp. 2931-2936. 10.1152/jn.00125.2016. Green open access

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Abstract

Imaging techniques such as functional magnetic resonance imaging seek to estimate neural signals in local brain regions through measurements of hemodynamic activity. However, hemodynamic activity is accompanied by large vascular fluctuations of unclear significance. To characterize these fluctuations and their impact on estimates of neural signals, we used optical imaging in visual cortex of awake mice. We found that hemodynamic activity can be expressed as the sum of two components, one local and one global. The local component reflected presumed neural signals driven by visual stimuli in the appropriate retinotopic region. The global component constituted large fluctuations shared by larger cortical regions, which extend beyond visual cortex. These fluctuations varied from trial to trial, but they did not constitute noise; they correlated with pupil diameter, suggesting that they reflect variations in arousal or alertness. Distinguishing local and global contributions to hemodynamic activity may help understand neurovascular coupling and interpret measurements of hemodynamic responses.

Type: Article
Title: Local and global contributions to hemodynamic activity in mouse cortex
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/jn.00125.2016
Publisher version: http://dx.doi.org/10.1152/jn.00125.2016
Additional information: © The American Physiological Society. Licensed under Creative Commons Attribution CC-BY 3.0
Keywords: brain imaging, hemodynamic activity, neurovascular coupling
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1481027
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