UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Regulation of Axonal Transport by Protein Kinases

Gibbs, KL; Greensmith, L; Schiavo, G; (2015) Regulation of Axonal Transport by Protein Kinases. Trends in Biochemical Sciences , 40 (10) pp. 597-610. 10.1016/j.tibs.2015.08.003. Green open access

[thumbnail of Schiavo_TIBS-D-15-00126.pdf]
Preview
Text
Schiavo_TIBS-D-15-00126.pdf - Accepted Version

Download (894kB) | Preview

Abstract

The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic dynein, which carry their cargoes along microtubule tracks. Protein kinases regulate axonal transport through direct phosphorylation of motors, adapter proteins, and cargoes, and indirectly through modification of the microtubule network. The misregulation of axonal transport by protein kinases has been implicated in the pathogenesis of several nervous system disorders. Here, we review the role of protein kinases acting directly on axonal transport and discuss how their deregulation affects neuronal function, paving the way for the exploitation of these enzymes as novel drug targets.

Type: Article
Title: Regulation of Axonal Transport by Protein Kinases
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibs.2015.08.003
Publisher version: http://dx.doi.org/10.1016/j.tibs.2015.08.003
Language: English
Additional information: Copyright © 2015 Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, CULTURED HIPPOCAMPAL-NEURONS, GLYCOGEN-SYNTHASE KINASE-3, AMYLOID PRECURSOR PROTEIN, LEMUR TYROSINE KINASE-2, CYTOPLASMIC DYNEIN, RETROGRADE TRANSPORT, IN-VIVO, C-JUN, ANTEROGRADE TRANSPORT, TAU PHOSPHORYLATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1480353
Downloads since deposit
697Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item