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Ophthalmic statistics note 8: missing data - exploring the unknown

Bunce, C; Quartilho, A; Freemantle, N; Doré, CJ; Ophthalmic Statistics Group; (2016) Ophthalmic statistics note 8: missing data - exploring the unknown. [Editorial comment]. British Journal of Ophthalmology , 100 (3) pp. 291-294. 10.1136/bjophthalmol-2015-307821. Green open access

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Abstract

Medical research is conducted to answer uncertainties and to identify effective treatments for patients. Different questions are best addressed by different types of study design—but the randomised, controlled clinical trial is typically viewed as the gold standard, providing a very high level of evidence, when examining efficacy. While clinical trial methodology has advanced considerably with clear guidance provided as to how to avoid sources of bias, even the most robustly designed study can succumb to missing data. In this statistics note, we discuss strategies for dealing with missing data but what we hope emerges is a very clear message that there is no ideal solution to missing data and prevention is the best strategy.

Type: Article
Title: Ophthalmic statistics note 8: missing data - exploring the unknown
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bjophthalmol-2015-307821
Publisher version: http://dx.doi.org/10.1136/bjophthalmol-2015-307821
Language: English
Additional information: This article has been accepted for publication in the British Journal of Ophthalmology following peer review. The definitive copyedited, typeset version, Bunce, C; Quartilho, A; Freemantle, N; Doré, CJ; Ophthalmic Statistics Group, ; (2016) Ophthalmic statistics note 8: missing data - exploring the unknown. British Journal of Ophthalmology, 100 (3) pp. 291-294, is available online at: http://dx.doi.org/10.1136/bjophthalmol-2015-307821.
Keywords: Clinical Trial, Epidemiology, Medical Education, Vision
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1479894
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