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Clinical relevance of corrosion patterns attributed to inflammatory cell-induced corrosion: A retrieval study

Di Laura, A; Hothi, HS; Meswania, JM; Whittaker, RK; de Villiers, D; Zustin, J; Blunn, GW; ... Hart, AJ; + view all (2017) Clinical relevance of corrosion patterns attributed to inflammatory cell-induced corrosion: A retrieval study. Journal of Biomedical Materials Research Part B: Applied Biomaterials , 105 (1) pp. 155-164. 10.1002/jbm.b.33540. Green open access

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Abstract

In vitro studies have shown that human osteoclasts can corrode stainless steel and titanium leading to the production of metal ions responsible for inflammatory reactions. Moreover, traces of cellular activities on metal orthopaedic explants have recently been reported as inflammatory cell-induced (ICI) corrosion being the result of the cells sealing on the metal surfaces and releasing reactive oxygen species (ROS) through Fenton-like reactions. The extent and clinical relevance of this phenomenon has yet to be understood. We analysed a cohort of 100 CoCr alloy hips collected at our retrieval centre; we performed macroscopic and microscopic screening and used statistical analysis to correlate our findings with implant and clinical variables. We found that 59% of our implants had evidence of surface damage consistent with what has previously been described as cell-induced corrosion. There was a significant association between the patterns and aseptic loosening for the ASR modular (r = -0.488, p = 0.016) and the Durom modular (r = 0.454, p = 0.026). This is the largest implant retrieval study to examine the phenomena of so-called ICI corrosion and is the first to investigate its clinical relevance. We recommend further work to determine the role of cells in the damage patterns observed. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

Type: Article
Title: Clinical relevance of corrosion patterns attributed to inflammatory cell-induced corrosion: A retrieval study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jbm.b.33540
Publisher version: http://doi.org/10.1002/jbm.b.33540
Language: English
Additional information: This is the peer reviewed version of the following article: Di Laura, A; Hothi, HS; Meswania, JM; Whittaker, RK; de Villiers, D; Zustin, J; Blunn, GW; (2017) Clinical relevance of corrosion patterns attributed to inflammatory cell-induced corrosion: A retrieval study. Journal of Biomedical Materials Research part B Applied Biomaterials , 105 (1) pp. 155-164. 10.1002/jbm.b.33540, which has been published in final form at 10.1002/jbm.b.33540. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: CoCr, cell, corrosion, inflammation, orthopaedic implants
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1479881
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