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Enabling research with human embryonic and fetal tissue resources

Gerrelli, D; Lisgo, S; Copp, AJ; Lindsay, S; (2015) Enabling research with human embryonic and fetal tissue resources. Development , 142 (18) pp. 3073-3076. 10.1242/dev.122820. Green open access

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Abstract

Congenital anomalies are a significant burden on human health. Understanding the developmental origins of such anomalies is key to developing potential therapies. The Human Developmental Biology Resource (HDBR), based in London and Newcastle, UK, was established to provide embryonic and fetal material for a variety of human studies ranging from single gene expression analysis to large-scale genomic/transcriptomic studies. Increasingly, HDBR material is enabling the derivation of stem cell lines and contributing towards developments in tissue engineering. Use of the HDBR and other fetal tissue resources discussed here will contribute to the long-term aims of understanding the causation and pathogenesis of congenital anomalies, and developing new methods for their treatment and prevention.

Type: Article
Title: Enabling research with human embryonic and fetal tissue resources
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.122820
Publisher version: http://doi.org/10.1242/dev.122820
Language: English
Additional information: © 2015. Published by The Company of Biologists Ltd.
Keywords: Science & Technology, Life Sciences & Biomedicine, Developmental Biology, Bioinformatics portals, Congenital anomalies, Gene expression, Human development, Human embryo, Tissue bank, DNA ELEMENTS, HUMAN BRAIN, FOLIC-ACID, EXPRESSION, GENOME, TRANSCRIPTOME, MUTATIONS, EVOLUTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1479612
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