UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Magnetic sentinel node and occult lesion localization in breast cancer (MagSNOLL Trial)

Ahmed, M; Anninga, B; Goyal, S; Young, P; Pankhurst, QA; Douek, M; (2015) Magnetic sentinel node and occult lesion localization in breast cancer (MagSNOLL Trial). British Journal of Surgery , 102 (6) pp. 646-652. 10.1002/bjs.9800. Green open access

[img]
Preview
Text
Pankhurst_2015 BJS MagSNOLL.pdf

Download (455kB) | Preview

Abstract

BACKGROUND: Non‐palpable breast cancers require localization‐guided surgery and axillary staging using sentinel lymph node biopsy (SLNB). This study investigated the novel technique of magnetic‐guided lesion localization and concurrent SLNB, which avoids the need for wire‐guided localization and radioisotopes. METHODS: An ultrasound‐guided intratumoral injection of magnetic tracer (0·5 ml) was performed in a protocol‐driven predefined minimum of ten patients with palpable breast cancer to assess the ability of the magnetic tracer safely to localize the tumour at the site of injection and concurrently drain to the lymphatics. Once successful lesion localization had been confirmed (peak magnetometer count retained at the centre of the tumour), the technique was undertaken in a further 20 patients with non‐palpable breast cancers awaiting wide local excision and SLNB. All patients underwent SLNB with both the magnetic and standard dual (radioisotope and Patent Blue V dye) techniques. RESULTS: Thirty‐two patients were recruited, of whom 12 (1 with bilateral disease) presented with palpable and 20 with non‐palpable breast cancer. Peak magnetometer counts were retained at the tumour centre in all palpable (13) and non‐palpable (20) breast cancers. Re‐excisions for involved margins were necessary in two patients with non‐palpable breast cancers. The sentinel lymph node identification rates were 28 of 33 procedures for the magnetic technique alone, 32 of 33 for the magnetic technique combined with blue dye, and 32 of 33 for the standard dual technique. CONCLUSION: Magnetic lesion localization is feasible, with intratumoral magnetic tracer injection combined with a periareolar injection of blue dye for subsequent SNLB.

Type: Article
Title: Magnetic sentinel node and occult lesion localization in breast cancer (MagSNOLL Trial)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/bjs.9800
Publisher version: https://doi.org/10.1002/bjs.9800
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Surgery, superparamagnetic iron-oxide, wire-guided localization, biopsy, dissection, surgery, nanoparticles, metaanalysis, ultrasound
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1479444
Downloads since deposit
148Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item