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Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis

Hauser, TU; Fiore, VG; Moutoussis, M; Dolan, RJ; (2016) Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis. Trends in Neurosciences , 39 (2) pp. 63-73. 10.1016/j.tins.2015.12.009. Green open access

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Abstract

Attention-deficit hyperactivity disorder (ADHD), one of the most common psychiatric disorders, is characterised by unstable response patterns across multiple cognitive domains. However, the neural mechanisms that explain these characteristic features remain unclear. Using a computational multilevel approach, we propose that ADHD is caused by impaired gain modulation in systems that generate this phenotypic increased behavioural variability. Using Marr's three levels of analysis as a heuristic framework, we focus on this variable behaviour, detail how it can be explained algorithmically, and how it might be implemented at a neural level through catecholamine influences on corticostriatal loops. This computational, multilevel, approach to ADHD provides a framework for bridging gaps between descriptions of neuronal activity and behaviour, and provides testable predictions about impaired mechanisms.

Type: Article
Title: Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2015.12.009
Publisher version: http://dx.doi.org/10.1016/j.tins.2015.12.009
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Attention-deficit hyperactivity disorder (ADHD), behavioural variability, computational psychiatry, dopamine, neural gain, noradrenaline, norepinephrine
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1478887
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