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Neurodevelopment and ages of onset in depressive disorders

Hagan, CC; Graham, JM; Wilkinson, PO; Midgley, N; Suckling, J; Sahakian, BJ; Goodyer, IM; (2015) Neurodevelopment and ages of onset in depressive disorders. Lancet Psychiatry , 2 (12) pp. 1112-1116. 10.1016/S2215-0366(15)00362-4. Green open access

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Abstract

How and why do clinical depressive disorders emerge in adolescence? In this Personal View, we present a neurodevelopmental theory to address causes for adolescent onsets of clinical depressive disorders. We argue that theories should account for three perplexing aspects of depressive disorders in adolescence: the episodic nature of depression; differences between sexes in rates of depression across development; and age-differentiated onsets. We consider how theories such as psychosocial acceleration, heterochronic brain development, dual-process models, glucocorticoid vulnerability hypothesis linked to early life stress, and epigenetic and genetic susceptibility might explain some aspects of adolescent depressive disorders. We argue that some synthesis between existing theories might be needed to establish a sufficient neurodevelopmental theoretical framework to explain onsets of depressive disorders in adolescence.

Type: Article
Title: Neurodevelopment and ages of onset in depressive disorders
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S2215-0366(15)00362-4
Publisher version: http://dx.doi.org/10.1016/S2215-0366(15)00362-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1478487
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