UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A new era of pulmonary delivery of nano-antimicrobial therapeutics to treat chronic pulmonary infections

Merchant, Z; Buckton, G; Taylor, KM; Stapleton, P; Saleem, IY; Gulrez Zariwala, M; Somavarapu, S; (2016) A new era of pulmonary delivery of nano-antimicrobial therapeutics to treat chronic pulmonary infections. Current Pharmaceutical Design , 22 (17) pp. 2577-2598. 10.2174/1381612822666160317142139. Green open access

[thumbnail of A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections.pdf]
Preview
Text
A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections.pdf

Download (767kB) | Preview

Abstract

Pulmonary infections may be fatal especially in immunocompromised patients and patients with underlying pulmonary dysfunction, such as those with cystic fibrosis, chronic obstructive pulmonary disorder, etc. According to the WHO, lower respiratory tract infections ranked first amongst the leading causes of death in 2012, and tuberculosis was included in the top 10 causes of death in low income countries, placing a considerable strain on their economies and healthcare systems. Eradication of lower respiratory infections is arduous, leading to high healthcare costs and requiring higher doses of antibiotics to reach optimal concentrations at the site of pulmonary infection for protracted period. Hence direct inhalation to the respiratory epithelium has been investigated extensively in the past decade, and seems to be an attractive approach to eradicate and hence overcome this widespread problem. Moreover, engineering inhalation formulations wherein the antibiotics are encapsulated within nanoscale carriers could serve to overcome many of the limitations faced by conventional antibiotics, like difficulty in treating intracellular pathogens such as mycobacteria spp. and salmonella spp., biofilm-associated pathogens like Pseudomonas aeruginosa and Staphylococcus aureus, passage through the sputum associated with disorders like cystic fibrosis and chronic obstructive pulmonary disorder, systemic side effects following oral/parenteral delivery and inadequate concentrations of antibiotic at the site of infection leading to resistance. Encapsulation of antibiotics in nanocarriers may help in providing a protective environment to combat antibiotic degradation, confer controlled-release properties, hence reducing dosing frequency, and may increase uptake via specific and non-specific targeting modalities. Hence nanotechnology combined with direct administration to the airways using commercially available delivery devices, is a highly attractive formulation strategy to eradicate microorganisms from the lower respiratory tract, which might otherwise present opportunities for multi-drug resistance.

Type: Article
Title: A new era of pulmonary delivery of nano-antimicrobial therapeutics to treat chronic pulmonary infections
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1381612822666160317142139
Publisher version: http://dx.doi.org/10.2174/138161282266616031714213...
Language: English
Additional information: This is the accepted manuscript version of the article published in Current Pharmaceutical Design; the published article is available at EurekaSelect via http://dx.doi.org/10.2174/1381612822666160317142139
Keywords: Bacterial resistance; biofilm; cystic fibrosis; infection; nanoparticle; liposome; pulmonary; tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1478131
Downloads since deposit
419Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item