Melchionda, M;
Pittman, JK;
Mayor, R;
Patel, S;
(2016)
Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo.
Journal of Cell Biology
, 212
(7)
pp. 803-813.
10.1083/jcb.201510019.
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Abstract
Increasing evidence implicates Ca(2+)in the control of cell migration. However, the underlying mechanisms are incompletely understood. Acidic Ca(2+)stores are fast emerging as signaling centers. But how Ca(2+)is taken up by these organelles in metazoans and the physiological relevance for migration is unclear. Here, we identify a vertebrate Ca(2+)/H(+)exchanger (CAX) as part of a widespread family of homologues in animals. CAX is expressed in neural crest cells and required for their migration in vivo. It localizes to acidic organelles, tempers evoked Ca(2+)signals, and regulates cell-matrix adhesion during migration. Our data provide new molecular insight into how Ca(2+)is handled by acidic organelles and link this to migration, thereby underscoring the role of noncanonical Ca(2+)stores in the control of Ca(2+)-dependent function.
| Type: | Article |
|---|---|
| Title: | Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1083/jcb.201510019 |
| Publisher version: | http://dx.doi.org/10.1083/jcb.201510019 |
| Language: | English |
| Additional information: | Copyright © 2016 Melchionda et al. Published by The Rockefeller University Press and available at http://dx.doi.org/10.1083/jcb.201510019. This article (Melchionda, M; Pittman, JK; Mayor, R; Patel, S; (2016) Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo. Journal of Cell Biology , 212 (7) pp. 803-813. 10.1083/jcb.201510019) is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1478115 |
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