Nayyer, L;
Jell, G;
Esmaeili, A;
Birchall, M;
Seifalian, AM;
(2016)
A Biodesigned Nanocomposite Biomaterial for Auricular Cartilage Reconstruction.
Advanced Healthcare Materials
, 5
(10)
pp. 1203-1212.
10.1002/adhm.201500968.
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Abstract
Current biomaterials for auricular replacement are associated with high rates of infection and extrusion. The development of new auricular biomaterials that mimic the mechanical properties of native tissue and promote desirable cellular interactions may prevent implant failure. A porous 3D nanocomposite scaffold (NS) based on POSS-PCU (polyhedral oligomeric silsesquioxane nanocage into polycarbonate based urea-urethane) is developed with an elastic modulus similar to native ear. In vitro biological interactions on this NS reveal greater protein adsorption, increased fibroblast adhesion, proliferation, and collagen production compared with Medpor (the current synthetic auricular implant). In vivo, the POSS-PCU with larger pores (NS2; 150-250 μm) have greater tissue ingrowth (≈5.8× and ≈1.4 × increase) than the POSS-PCU with smaller pores (NS1; 100-50 μm) and when compared to Medpor (>100 μm). The NS2 with the larger pores demonstrates a reduced fibrotic encapsulation compared with NS1 and Medpor (≈4.1× and ≈1.6×, respectively; P < 0.05). Porosity also influences the amount of neovascularization within the implants, with no blood vessel observed in NS1 (12 weeks postimplantation). The lack of chronic inflammatory response for all materials may indicate that the elastic modulus and pore size of the implant scaffold could be important design considerations for influencing fibrotic responses to auricular and other soft tissue implants.
| Type: | Article |
|---|---|
| Title: | A Biodesigned Nanocomposite Biomaterial for Auricular Cartilage Reconstruction |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adhm.201500968 |
| Publisher version: | http://dx.doi.org/10.1002/adhm.201500968 |
| Language: | English |
| Additional information: | Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: [Nayyer, L., Jell, G., Esmaeili, A., Birchall, M. and Seifalian, A. M. (2016), A Biodesigned Nanocomposite Biomaterial for Auricular Cartilage Reconstruction. Advanced Healthcare Materials, 5: 1203–1212. doi: 10.1002/adhm.201500968], which has been published in final form at http://dx.doi.org/10.1002/adhm.201500968. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: | Medpor, POSS-PCU, auricular cartilage, biomaterial, nanocomposite scaffold |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1477981 |
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