Vaz-Pereira, S;
Zarranz-Ventura, J;
Sim, DA;
Keane, PA;
Smith, R;
Egan, CA;
Tufail, A;
(2016)
Optical Coherence Tomography Features of Active and Inactive Retinal Neovascularization in Proliferative Diabetic Retinopathy.
Retina
, 36
(6)
pp. 1132-1142.
10.1097/IAE.0000000000000869.
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Abstract
PURPOSE: To describe spectral domain-optical coherence tomography features of retinal neovascularization in proliferative diabetic retinopathy and thus to identify novel signs of new vessel activity. METHODS: Retrospective, cross-sectional study. Data were collected over a 9-month period. Spectral domain optical coherence tomography scans were performed over areas of new vessel complexes (NVC) in both the disk and elsewhere, and were qualitatively graded by two masked observers. New vessel complexes activity was determined using clinical and angiographic criteria and correlated with spectral domain optical coherence tomography features. RESULTS: Forty-three eyes of 30 patients with proliferative diabetic retinopathy were included. Sixty-one NVC lesions (neovascularization of the disk—37.7%, neovascularization elsewhere—62.3%) were captured by spectral domain-optical coherence tomography and analyzed. Among them, 63.9% were classified as active and 36.1% as quiescent. Five distinctive features were identified as significantly different between active and quiescent NVC: the presence of vitreous hyperreflective dots in active NVC (P = 0.002) and the presence of epiretinal membrane (P = 0.04), inner retinal tissue contracture (P = 0.03), vitreous invasion (P = 0.02), and protrusion towards vitreous (P = 0.002) in quiescent NVC. CONCLUSION: In this exploratory study, the presence of vitreous hyperreflective dots, epiretinal membrane, inner retinal tissue contracture, vitreous invasion, and vitreous protrusion were identified as distinct signs of disease activity. Such parameters may be useful as a noninvasive imaging modality in eyes undergoing treatment for proliferative diabetic retinopathy.
| Type: | Article |
|---|---|
| Title: | Optical Coherence Tomography Features of Active and Inactive Retinal Neovascularization in Proliferative Diabetic Retinopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/IAE.0000000000000869 |
| Publisher version: | http://dx.doi.org/10.1097/IAE.0000000000000869 |
| Language: | English |
| Additional information: | Copyright: © 2016 by Ophthalmic Communications Society, Inc. This is a non-final version of an article published in final form in Retina [Vaz-Pereira, S; Zarranz-Ventura, J; Sim, DA; Keane, PA; Smith, R; Egan, CA; Tufail, A; (2016) Optical Coherence Tomography Features of Active and Inactive Retinal Neovascularization in Proliferative Diabetic Retinopathy. Retina , 36 (6) pp. 1132-1142. 10.1097/IAE.0000000000000869]. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, diabetes mellitus, diabetic retinopathy, neovascularization of the disk, retinal neovascularization, spectral domain-optical coherence tomography, Macular Edema, Hyperreflective Dots, Photocoagulation, Prevalence, Age |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1477599 |
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