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Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw

Fung, PL; Nicoletti, P; Shen, Y; Porter, S; Fedele, S; (2015) Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw. Oral and Maxillofacial Surgery Clinics of North America , 27 (4) pp. 537-546. 10.1016/j.coms.2015.06.005. Green open access

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Abstract

Osteonecrosis of the jaws (ONJ) is a potentially severe disorder that develops in a subgroup of individuals who have used bisphosphonate (BP) medications. Several clinical risk factors have been associated with the risk of ONJ development, but evidence is limited and in most instances ONJ remains an unpredictable adverse drug reaction. Interindividual genetic variability can contribute to explaining ONJ development in a subset of BP users and the discovery of relevant associated gene variants could lead to the identification of individuals at higher risk. No genetic variant has been found to be robustly associated with susceptibility to ONJ.

Type: Article
Title: Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coms.2015.06.005
Publisher version: http://dx.doi.org/10.1016/j.coms.2015.06.005
Language: English
Additional information: Copyright © 2015 Elsevier Inc. This manuscript is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Bisphosphonates, Genes, Jaw osteonecrosis, Pharmacogenetics, Pharmacogenomics, Single-nucleotide polymorphisms
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1477477
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