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Cerebrospinal Fluid Biomarkers for Huntington's Disease.

Byrne, LM; Wild, EJ; (2016) Cerebrospinal Fluid Biomarkers for Huntington's Disease. Journal of Huntington’s Disease , 5 (1) pp. 1-13. 10.3233/JHD-160196. Green open access

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Abstract

Cerebrospinal fluid (CSF) is enriched in brain-derived components and represents an accessible and appealing means of interrogating the CNS milieu to study neurodegenerative diseases and identify biomarkers to facilitate the development of novel therapeutics. Many such CSF biomarkers have been proposed for Huntington's disease (HD) but none has been validated for clinical trial use. Across many studies proposing dozens of biomarker candidates, there is a notable lack of statistical power, consistency, rigor and validation. Here we review proposed CSF biomarkers including neurotransmitters, transglutaminase activity, kynurenine pathway metabolites, oxidative stress markers, inflammatory markers, neuroendocrine markers, protein markers of neuronal death, proteomic approaches and mutant huntingtin protein itself. We reflect on the need for large-scale, standardized CSF collections with detailed phenotypic data to validate and qualify much-needed CSF biomarkers for clinical trial use in HD.

Type: Article
Title: Cerebrospinal Fluid Biomarkers for Huntington's Disease.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JHD-160196
Publisher version: http://dx.doi.org/10.3233/JHD-160196
Language: English
Additional information: This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC-BY). For more information see https://creativecommons.org/licenses/by/4.0/.
Keywords: Huntington’s disease, biomarkers, cerebrospinal fluid, clinical trial, disease progression, neurodegenerative disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1477470
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